Hierarchical Bayesian Modeling of Pharmacophores in Bioinformatics
نویسندگان
چکیده
منابع مشابه
Hierarchical bayesian modeling of pharmacophores in bioinformatics.
One of the key ingredients in drug discovery is the derivation of conceptual templates called pharmacophores. A pharmacophore model characterizes the physicochemical properties common to all active molecules, called ligands, bound to a particular protein receptor, together with their relative spatial arrangement. Motivated by this important application, we develop a Bayesian hierarchical model ...
متن کاملHierarchical Bayesian Modelling of Pharmacophores in Bioinformatics
One of the key ingredients in drug discovery is the derivation of conceptual templates called pharmacophores. A pharmacophore model characterises the physico-chemical properties common to all active molecules, called ligands, bound to a particular protein receptor, together with their relative spatial arrangement. Motivated by this important application, we develop a Bayesian hierarchical model...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2010
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2010.01460.x